3499拉斯维加斯

• 刘翠平

• 系所

  基础兽医学系

• 职称

  教授

• 办公房间

  第一综合楼B420

• email

  cuiping.liu@mail.hzau.edu.cn

• 讲授课程

  《基础生物化学》、《基础兽医学进展》等

个人简介

刘翠平，女，湖北天门人，华中农业大学教授、博士生导师，致力于科学研究、人才培养和平台建设，重点从事生物化学与分子生物学的基础研究，探讨抗生素耐药、癌症及人兽共患病的分子机制，主持国家与湖北省自然科学基金面上项目各1项, 学校人才引进启动经费项目1项。研究成果发表在Nature Structural & Molecular Biology, Nature Communications, RNA, Journal of Biological Chemistry, Journal of Molecular Biology, Nucleic Acids Research等国际专业学术期刊上。

教育经历

1991.09 - 1995.07， 湖北省中医药大学，中药毕业，医学学士
1995.09 - 1998.07， 河南省中医药大学，药物化学专业毕业，医学硕士
1998.09 – 2001.07，中国科学院上海药物研究所，有机化学专业，理学博士

工作经历

2001.09-2003.10，瑞典Lund University细胞与分子生物学系，博士后
2003.10-2013.01，美国费城Thomas Jefferson University生化与分子生物学系，先后为博士后与助理研究人员
2013.01-至今， 华中农业大学动物医学院，教授

研究领域

核酸与酶的互作，及其在抗生素耐药，癌症及人兽共患病中的分子机制。

科研成果

A著作类
1.《动物生物化学》教材，2016年，高等教育出版社, 参编，撰写“酶”一章。

B论文类
Masuda I, Igarashi T, Sakaguchi R, Nitharwal RG, Takase R, Han KY, Leslie BJ, Liu C, Gamper H, Ha T, Sanyal S, Hou YM. A genetically encoded fluorescent tRNA is active in live-cell protein synthesis. Nucleic Acids Res. 2017 Apr 20;45(7):4081-4093. doi: 10.1093/nar/gkw1229.
Li M, Cai C, Chen J, Cheng C, Cheng G, Hu X, Liu C (Correspondence author). Inducible Expression of both ermB and ermT Conferred High Macrolide Resistance in Streptococcus gallolyticus subsp. pasteurianus Isolates in China. Int J Mol Sci. 2016 Sep 22;17(10). pii: E1599. doi: 10.3390/ijms17101599.
Liu C（Co-1st author）, Stonestrom AJ, Christian T, Yong J, Takase R, Hou YM, Yang X. Molecular Basis and consequences of the cytochrome c-tRNA interaction. Journal of Biological Chemistry. 2016; Mar 9. pii: jbc.M115.697789.
Kalamajski S, Liu C, Tillgren V, Rubin K, Oldberg ?, Rai J, Weis M, Eyre DR. Increased C-telopeptide cross-linking of tendon type I collagen in fibromodulin-deficient mice. Journal of Biological Chemistry. 2014; 289(27): 18873-9.
Masuda I, Sakaguchi R, Liu C, Gamper H, Hou YM. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD). Journal of Biological Chemistry. 2013; 288(40): 28987-96.
Liu C, Sanders J, Pascal J, Hou YM, Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases, RNA, 2012, 18(2): 213-21
Liu C, Gamper H., Liu H., Cooperman BS, Hou YM, Potential for the interdependent deve-lopment for aminoacylation and ribosome decoding, Nature Communications, 2011, 2 : 329
Igarashi T, Liu C (co-1st author), Hou YM, Pyrophosphorolysis of class II CCA addition: Implication for Fidelity, Journal of Molecular Biology, 2011, 414(1):28-43
Christian T, Lahoud G, Liu C, Hoffmann K, Perona JJ, Hou YM, Mechanism of N-methylation by the tRNA m1G methyltransferase Trm5. RNA. 2010, 16(12): 2484-92
McLaughlin HM, Sakaguchi R, Liu C, Igarashi T, Pehlivan D, Chu K, Iyer R, Cruz P, et al., Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy. American Journal of Human Genetics. 2010, 87(4):560-6
Christian T, Lahoud G, Liu C, Hou YM, Control of catalytic cycle by a pair of analogous tRNA modification enzymes. Journal of Molecular Biology. 2010, 400(2): 204-17
Liu C, Betteridge, T, Hou, YM. Fluorophore labeling to monitor tRNA dynamics. Methods Enzymol. (Editor Herschlag, D, Academic Press) 2009, 469: 69-93
Kim S, Liu C, Halkidis K, Gamper HB, Hou YM, Distinct kinetic determinants for the stepwise CCA addition to tRNA. RNA. 2009, 15(10):1827-36
Liu X, Silks LA, Liu C, Ollivault-Shiflett M., Huang X, Li J, Luo G, Hou YM, Liu J, Shen J. Incorporation of tellurocysteine into glutathione transferase generate high glutathione peroxidase efficiency. Angew Chem Int Ed Engl, 2009, 48(11): 2020-3
Zhang CM, Liu C (co-1st author), Slator S and Hou YM, Aminoacylation of tRNA with phosphoserine for synthesis of cysteinyl-tRNA(Cys), Nature Structural & Molecular Biology, 2008, 15(5):507-14
Zhang CM, Liu C, Christian T, Gamper H, Rozenski J, Pan D, Randolph JB, Wickstrom E, Cooperman BS, and Hou YM, Pyrrolo-C as a molecular probe for monitoring conformations of the tRNA 3

科研项目

1. 国家自然科学基金面上项目1项 2014-2017
2. 湖北省自然科学基金面上项目1项，2014-2015
3. 自主创新国际合作项目1项， 2014-2015

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